12 Results for "

Lithospermum canescens Lehm.

" in MedChemExpress (MCE) Product Catalog:
Products (12)

12 Results for "Lithospermum canescens Lehm." in MCE Product Catalog:

3
β,β-Dimethylacrylalkannin
β,β-Dimethylacrylalkannin
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3 Cited Publications
製品番号: HY-N5112A
CAS 番号: 34539-65-6
別名: Arnebin 1
Category:  

Quinones other families Other Diseases Plants Disease Research Fields Naphthalene Quinones Pteris livida Mett.

Target:  

FGFR Necroptosis Apoptosis CDK JNK

β,β-Dimethylacrylalkannin (Arnebin 1) is an orally active FGFR1 inhibitor (IC50=2.5 μM) and the main active component of Lithospermum erythrorhizon. β,β-Dimethylacrylalkannin blocks downstream signaling by binding to the ATP pocket of FGFR1, and regulates the CDK1/Cdc25C pathway and ROS-JNK axis, thereby inducing G2/M phase arrest, necrosis and apoptosis in cancer cells, and inhibiting tumor proliferation. β,β-Dimethylacrylalkannin also acts as a colistin adjuvant to disrupt the cell membrane of Gram-negative bacteria. β,β-Dimethylacrylalkannin exhibits significant tumor-inhibitory effects with no obvious toxicity in PDX models, but chronic exposure to high doses may alter the relative lung/liver weights of rats, while acute exposure to high doses causes responses such as reduced motor activity. β,β-Dimethylacrylalkannin finds wide application in studies related to hepatocellular carcinoma, colorectal cancer, colistin-resistant bacterial infections, hepatitis and psoriasis .
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Beta-Acetoxyisovalerylshikonin
Beta-Acetoxyisovalerylshikonin
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1 Cited Publications
製品番号: HY-N2188
CAS 番号: 69091-17-4
Category:  

Plants Boraginaceae Naphthalene Quinones Quinones other families Phenols Polyphenols Disease Research Fields Inflammation/Immunology Arnebia euchroma (Royle) Johnst.

Target:  

HIV

Beta-Acetoxyisovalerylshikonin is a naturally occurring naphthoquinone-type shikonin derivative that is widely distributed in the roots and cell suspension cultures of *Arnebia euchroma*, *Arnebia guttata*, *Onosma hispidum* and *Lithospermum erythrorhizon*. Beta-Acetoxyisovalerylshikonin exhibits favorable antibacterial, anti-inflammatory, wound-healing promoting and antioxidant activities, and also possesses potential anti-tumor and anti-HIV properties .
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β,β-Dimethylacrylshikonin
β,β-Dimethylacrylshikonin
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1 Cited Publications
製品番号: HY-N5112B
CAS 番号: 24502-79-2
別名: Isoarnebin I
Category:  

Quinones Phenols Polyphenols Plants Lithospermum erythrorhizon Sieb. et Zucc. Disease Research Fields Boraginaceae Naphthalene Quinones Cancer

Target:  

HIF/HIF Prolyl-Hydroxylase Apoptosis Notch NO Synthase Bcl-2 Family

β,β-Dimethylacrylshikonin (Isoarnebin I) is a naphthoquinone derivative that can be isolated from Lithospermum erythrorhizon Sieb. et Zucc. β,β-Dimethylacrylshikonin promotes angiogenesis by inducing eNOS, VEGF and HIF-1α expression through the PI3K-dependent pathway. β,β-Dimethylacrylshikonin inhibits Notch-1 activation. β,β-Dimethylacrylshikonin inhibtis tumor cell proliferation, induces tumor cell apoptosis, and inhibits tumor growth .
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Deserpidine
Deserpidine
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製品番号: HY-107339
CAS 番号: 131-01-1
純度:  98.78%
別名: Harmonyl
Category:  

Apocynaceae Alkaloids Piperidine Alkaloids Plants Rauwolfia canescens Indole Alkaloids

Target:  

Angiotensin-converting Enzyme (ACE)

Deserpidine (Harmonyl) is an alkaloid isolated from the root of Rauwolfia canescens related to Reserpine. Deserpidine is used as an antihypertensive agent and a tranquilizer. Deserpidine is a competitive angiotensin converting enzyme (ACE) inhibitor. Deserpidine also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex .
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Isobutylshikonin
Isobutylshikonin
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製品番号: HY-N2592
CAS 番号: 52438-12-7
Category:  

Quinones Phenols Polyphenols Plants Lithospermum canescens Lehm. Disease Research Fields Inflammation/Immunology Boraginaceae Naphthalene Quinones

Target:  

Others

Isobutylshikonin is a kind of shikonin pigments found in hairy root culture of Lithospermum canescens. Isobutylshikonin decreases cell viability induces marked changes in JA-4 cells with nuclear condensation and swelling in the presence of LPS (HY-D1056) .
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β-Hydroxyisovalerylshikonin
β-Hydroxyisovalerylshikonin
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製品番号: HY-N4201
CAS 番号: 7415-78-3
Category:  

Quinones Phenols Polyphenols Plants Lithospermum erythrorhizon Sieb. et Zucc. Disease Research Fields Boraginaceae Naphthalene Quinones Cancer

Target:  

EGFR Src

Beta-hydroxyisovalerylshikonin is a natural product isolated from Lithospermum erythrorhizon, acts as a potent inhibitor of protein tyrosine kinases (PTK), with IC50s of 0.7μM and 1μM for EGFR and v-Src receptor, respectively. Beta-hydroxyisovalerylshikonin is effective against a wide variety of tumor cell lines, and most efficiently induces cell-death in NCI-H522 and DMS114 cells .
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Suc-Phe-Ala-Ala-Phe-pNA
Suc-Phe-Ala-Ala-Phe-pNA
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製品番号: HY-P4582
CAS 番号: 110906-89-3
別名: Suc-FAAF-pNA
Target:  

Ser/Thr Protease

研究分野:  

Others

Suc-Phe-Ala-Ala-Phe-pNA (Suc-FAAF-pNA) is a chromogenic polypeptide substrate that can be used for the quantitative activity assay of intracellular subtilisin (ISP) and neutral metalloprotease (NPS) derived from Saccharomonospora canescens. Suc-Phe-Ala-Ala-Phe-pNA is hydrolyzed by the catalytic triad of mature proteases to release the chromophore pNA. Suc-Phe-Ala-Ala-Phe-pNA is applicable to enzymological studies .
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Diplomorphanin A
Diplomorphanin A
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製品番号: HY-N16836
CAS 番号: 1559076-44-6
別名: Farrerol 4',7-di-O-β-D-glucopyranoside
Category:  

Flavonoids Thymelaeaceae Plants Wikstroemia canescens (Wall.) Meisn. Other Flavonoids

Target:  

Others

Diplomorphanin A (Farrerol 4',7-di-O-β-D-glucopyranoside) is a C-methylated flavonoid compound that can be found in Diplomorpha canescens. Diplomorpha canescens exhibits anti-tumor activity .
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Deserpidine (Standard)
Deserpidine (Standard)
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製品番号: HY-107339R
CAS 番号: 131-01-1
別名: Harmonyl (Standard)
Category:  

Apocynaceae Alkaloids Piperidine Alkaloids Plants Rauwolfia canescens Indole Alkaloids

Target:  

Reference Standards Angiotensin-converting Enzyme (ACE)

Deserpidine (Standard) is the analytical standard of Deserpidine. This product is intended for research and analytical applications. Deserpidine (Harmonyl) is an alkaloid isolated from the root of Rauwolfia canescens related to Reserpine. Deserpidine is used as an antihypertensive agent and a tranquilizer. Deserpidine is a competitive angiotensin converting enzyme (ACE) inhibitor. Deserpidine also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex .
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Deoxyshikonofuran
Deoxyshikonofuran
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製品番号: HY-N15277
CAS 番号: 104056-81-7
Category:  

Phenols Polyphenols Plants Lithospermum erythrorhizon Sieb. et Zucc. Boraginaceae

Target:  

Endogenous Metabolite

Deoxyshikonofuran is a shikonofuran derivative that can be extracted from the shikonin-producing cell cultures of Lithospermum erythrorhizon. Deoxyshikonofuran can be used for the study of the shikonin biosynthetic pathway .
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5-Epilithospermoside
5-Epilithospermoside
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製品番号: HY-N2671
CAS 番号: 84799-31-5
Category:  

Alkaloids Other Alkaloids Plants Lithospermum officinale L. Boraginaceae

Target:  

Others

5-Epilithospermoside is a Alkaloids product that can be isolated from the roots of Lithospermum officinale. .
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Quinones Library
Quinones Library
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製品番号: HY-L243
91 compounds

Quinone compounds are a significant class of natural products featuring a conjugated quinone structure, widely distributed in plants, fungi, and microorganisms. Based on their core structures, they can be primarily categorized into benzoquinones, naphthoquinones, phenanthrenequinones, and anthraquinones, among others. This structural diversity endows quinone compounds with a broad spectrum of pharmacological activities, making them key components in traditional Chinese medicine (such as rhubarb, Lithospermum erythrorhizon, and Salvia miltiorrhiza). Modern research has confirmed that their activities encompass anti-tumor, anti-inflammatory, antibacterial, antiviral, antiplatelet aggregation, and neuroprotective effects, among others, establishing them as an important source for drug development.

MCE designs a unique collection of 91 quinones that all come from natural products. MCE Quinones Library is a useful tool for drug discovery that can be used for high throughput screening (HTS) and high content screening (HCS).

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